Teresa Carlomagno's Tubulin-Binding Agents: Synthetic, Structural and PDF

By Teresa Carlomagno

ISBN-10: 3540690360

ISBN-13: 9783540690368

ISBN-10: 3642435947

ISBN-13: 9783642435942

experiences. The SAR facts are mentioned in mild of the structural details to be had for every agent. the second one bankruptcy makes a speciality of the complete synthesis of the marine sponge-derived polyketide discodermolide. A entire survey of the factitious chemistry efforts of numerous teams over a 14-year interval is supplied including a compa- son of the various ways. The 3rd bankruptcy describes a complete learn of the mechanisms of task of microtubules stabilizing medicines. Thermodynamic, kinetic, structural and fu- tional information on microtubules stabilizing medicinal drugs are mentioned in an interdisciplinary demeanour to generate a “time-resolved” photograph of the interplay of the medicine with assorted tubulin types. The fourth and 5th chapters assessment the efforts and achievements made within the characterization of the constitution of the complexes of tubulin with microtubules stabilizing brokers by means of NMR (Chapter four) and EM (Chapter 5). specifically obtrusive is the discrepancy of the implications bought for epothilones, the place the 2 options convey significantly diversified constructions of the certain drug. either NMR and EM types are, even if, capable of clarify a constant set of SAR information. The authors of the 2 chapters talk about significantly the benefits and obstacles of every methodology.

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Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights (Topics in Current Chemistry) by Teresa Carlomagno

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